A review published in European Urology Focus looks at tools to optimise the choice and sequence of treatments to ensure the best clinical benefit for their metastatic renal cell carcinoma (RCC) patients. The review concludes that the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk model is currently the only validated tool that can help clinicians decide which patients should receive sunitinib versus a combination of nivolumab and ipilimumab as a first treatment for metastatic RCC. Other tools are being actively investigated in clinical trials.
Predictive biomarkers in metastatic kidney cancer
23 May 2019
biological markers
biomarkers
IMDC
ipilimumab
nivolumab
Opdivo
renal cell carcinoma
sunitinib
Sutent
Yervoy
Most used tags
renal cell carcinoma immunotherapy combination therapy checkpoint inhibitors Cancer nivolumab TKIs overall survival Opdivo sunitinib Sutent progression-free survival cabozantinib biomarkers NHS England Cabometyx ipilimumab COVID-19 pembrolizumab cancer survival axitinib VEGF inhibitors non-clear cell kidney cancer Inlyta coronavirus Yervoy risk factors Keytruda metastases adjuvant therapy biological markers targeted therapy papillary RCC everolimus Afinitor ASCO cancer outcomes first-line treatment NICE partial nephrectomyArchives
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