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A retrospective study looked at the clinical and surgical outcomes in 11 patients with metastatic clear cell renal cell carcinoma (RCC) who had a delayed nephrectomy following a complete response to immunotherapy or immunotherapy and targeted therapy combinations.
There were surgical difficulties in 81.8% of cases caused by adhesions and inflammatory reactions. At 15 months after surgery, 73% of patients did not have progression of their cancer and 1 year following surgery 53% of patients were not receiving systemic treatment.
Although this is a small study, the results highlight the challenges of delayed nephrectomy in patients who have had prior immunotherapy treatment.