Hereditary leiomyomatosis and renal cell carcinoma (HLRCC)

A very rare inherited condition, in which patients are at risk of developing non-cancerous (benign) tumours in the muscle under the skin (cutaneous leiomyomas), in the womb of women (uterine leiomyomas), and eventually a very aggressive form of type 2 papillary kidney cancer (type 2 pRCC). HLRCC is caused by a change (mutation) in a gene called the fumarate hydratase (FH) gene.