Using the National Cancer Database, 3009 patients with low stage renal cell carcinoma (RCC) were identified as having undergone radical (2454 patients) or partial (555 patients) nephrectomy and were younger than 50 years. Median follow-up was 108.6 months during which 297 patients (12.1%) in the radical nephrectomy arm and 58 patients (10.5%) in the partial nephrectomy arm died.

This study showed that there was no difference in long-term overall survival between young, healthy patients who had radical versus partial nephrectomy. Being young and relatively healthy, these patients may have sufficient renal reserve over their lifetime such that preserving renal function by partial nephrectomy may be unnecessary.

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