Studies in mice suggest that tweaking cholesterol levels with avasimibe, a lipid-lowering drug, may boost the effectiveness of new immunotherapy drugs, such as nivolumab (Opdivo) and pembrolizumab (Keytruda). Adding avasimibe to PD-1 inhibitors improved tumour inhibition and increased survival in mice.
Cholesterol pill boosts cancer immunotherapy
21 Mar 2016
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renal cell carcinoma immunotherapy combination therapy checkpoint inhibitors Cancer nivolumab TKIs overall survival Opdivo sunitinib Sutent progression-free survival cabozantinib biomarkers NHS England Cabometyx ipilimumab pembrolizumab COVID-19 cancer survival axitinib VEGF inhibitors non-clear cell kidney cancer Inlyta coronavirus Yervoy risk factors Keytruda metastases adjuvant therapy biological markers papillary RCC targeted therapy everolimus Afinitor ASCO cancer outcomes first-line treatment NICE partial nephrectomyArchives
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