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The use of artificial intelligence (AI) in clinical practice using immunotherapy to treat cancer (immuno-oncology) is still in its infancy. However, AI has potential for overcoming some of the current challenges in immuno-oncology. Professor Thomas Powles, St Bartholomew’s Hospital, London, and Professor Pedro Romero, UNIL Ludwig Institute for Cancer Research, Lausanne, Switzerland discussed the promises and challenges of integrating AI technologies into clinical practice during an educational session at the European Society of Medical Oncology (ESMO) Immuno-oncology Congress in Geneva last week.