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The following OncLive interview with leading renal cell carcinoma (RCC) expert, Dr Toni Choueiri from the Dana-Farber Cancer Institute in Boston, US, discusses the data from the JAVELIN-101 study comparing the avelumab/axitinib combination with sunitinib in patients with previously untreated RCC. Dr Choueiri goes on to discuss where these data fit into the complex treatment paradigm of RCC.