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A recent study published in Journal of Clinical Medicine last month provides evidence for the expression of PD-1 and CTLA-4 receptors on white blood cells (tumour-infiltrating mononuclear cells) to be associated with a worse overall survival in patient with renal cell carcinoma (RCC).
The combination of PD-1 and CTLA-4 expression in tumour-infiltrating mononuclear cells might identify patients at high risk.